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Taken together, an inverted U-shaped relationship is postulated for levels of CoQ and oxidative stress: an increase of oxidative stress is only manifested under moderate CoQ 10 deficiency (3050% residual CoQ 10 ), whereas a more severe or milder deficit of CoQ 10 ( 50% of normal level) is not accompanied by overproduction of ROS (FIGURE 12) (113, 336)

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